Nana Shapiro is Isabella Garcia-Shapiro's grandmother. She resides at the Danville Senior Lodge.
Nana Shapiro is laid-back, she doesn't get the big problems to overcome her. Despite of this she can be very shy.
- "Lotsa Latkes" (First appearance)
- "A Phineas and Ferb Family Christmas" (Cameo)
- "Operation Crumb Cake"
- "Act Your Age"
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