Mrs. Pierpoint is Principal Lang's secretary in Danville High School. She is seen in the episode Doof 101, where she only appears in his office when he voices his disapproval of having Dr. Doofenshmirtz to work in his school as a teacher. She learns that Lang himself was an old college rival of Doofenshmirtz during the '80s, and that he was jealous when Doofenshmirtz had won the heart of Charlene at that time. Mrs. Pierpoint points out that both Doofenshmirtz and Charlene are divorced and attempts to convince her boss to give up his grudge, but he stubbornly refuses.
- "Doof 101"(First appearance)