After facing the choice of imprisonment or community service, Doof becomes a teacher at Vanessa's school. Meanwhile, a trio of bugs embark on a journey to become the first insects to communicate with humans. Phineas and Ferb make modifications to their school playground.
Vanessa meeting her friends Becky and Lacie in school
Vanessa is shocked to find out that her father will be teaching her class
Principal Lang introducing Doofenshmirtz to the class as their new science teacher
Doofenshmirtz explaining about his major
Vanessa feeling embarrassed
Doof assuring to Principal Lang that he'll do fine with the class
Principal Lang swearing that he'll be watching Doofenshmirtz
Doofenshmirtz attempting to spell out his name to the class
Vanessa interrupting during mid-intro
Vanessa pulling her dad away from the classroom to talk to him
Vanessa being upset to have her father as her new science teacher
Principal Lang is unhappy of having Doofenshmirtz to work here in his school
Lang is jealous that Doofenshmritz won Charlene's heart during college
Lang is told by Pierpoint that Doof and Charlene are divorced, but he is still jealous
Doofenshmirtz asking Johnny for a hair sample for a demonstration
Doofenshmirtz taking a hair follicle from Johnny's head
Doofenshmirtz placing the hair sample inside a Petri dish
Doof using the blackboard to show strands of DNA (embedded inside the hair sample) through the microscope to the class
Doofenshmirtz using the microscope to present out the properties of the DNA to the class
Doofenshmirtz explaining to the class about the genetic pairing of the DNA inside the hair sample
Napoleon and Wendell watching Doof giving his lecture from the floor
The bugs deciding to revealing themselves to the humans by climbing up to the table
Wendell trying to throw his hook on top of the table for him and his friends to climb
Wendell pulling a beaker by accident, causing several books to fall off
The bugs are now trapped inside the beaker
The books fall on a balance, sending out needles with string into the air
The needles trigger a chain reaction between a potato clock and a frog, causing the latter to kick the dish
Johnny being hit by the dish
Johnny growing a lizard tail after being hit by the dish, much to everyone's shock
Doofenshmirtz noticing that something is wrong with Johnny
Johnny's head transforming into that of a primate's
Johnny starting to act like an monkey
Vanessa is shocked to see Johnny mutating
Johnny panics as he is now mutated
Johnny running out from the classroom in fear
Major Monogram and Carl spotting Johnny running down the hallways through the school's surveillance system
Monogram decides to call in Perry to investigate the situation
Doofenshmirtz explains that he can use the hair sample to formulate an antidote to turn Johnny back to normal
Doofenshmirtz confessing to Perry about the event
Doofenshmirtz instructing Vanessa and several kids to help Perry find Johnny
Vanessa, Perry, and company sensing that Johnny is inside the school gym
Johnny hiding behind the gym bleachers
Vanessa trying to calm Johnny down, assuring that her dad will cure him
Johnny is scared to see an arriving Perry
Johnny grabbing Vanessa as he runs off
Johnny bursts out from the gym, taking Vanessa with him
Johnny running outside to the schoolyard
The bugs sitting on a trash can next to the table
The antidote is finished and ready to inject
Doofenshmirtz hears his daughter screaming
Johnny climbing the bell tower
Vanessa is annoyed at Johnny acting like a drama queen
Perry lending his hovercraft to fly Doof up to inject the antidote on Johnny
Perry helping Doofenshmirtz get a better shot
The mutated Johnny trying to avoid receiving the antidote
Johnny pushes a bell off the tower, much to Vanessa's shock
The bell falls from the tower
The bell lands on Perry, much to Doofenshmirtz's dismay
John P. Tristate Elementary School
Phineas and Ferb modifying their school playground for the other kids to enjoy
The hovercraft flying around the tower to get a clear shot
Phineas and Ferb watching the event
Phineas and Ferb proceeding to finish their project
Doofenshmritz trying to get the fallen bell off from Perry
Doofenshmirtz accidently falls into the ground with the bell, firing the syringe into the air
Vanessa catches the syringe
Vanessa injecting the antidote into Johnny's arm
Johnny turning back to normal thanks to the antidote
Perry saves both Vanessa and Johnny from falling
Perry watches as Doofenshmirtz and the class head back to their classroom in relief
Pricipal Lang arriving to the empty scene, wondering what has happened
The bugs finally made it to the table
Napoleon is confused about the banner that Wendell and Floyd are hoisting
Napoleon is annoyed by Wendell and Floyd's misspelling of their banner
Doofenshmirtz finishing his lecture before the bell rings
The students leave in relief while an unhappy Lang sulks over his failure to catch Doof in doing anything evil
Doofenshmirtz waving goodbye to the departing students
Vanessa deciding to accept her father as her teacher, but asking if any more incidents are to happen
Doofenshmirtz assuring to Vanessa that he'll try his best to avoid any more incidents
Vanessa being pleased with Doof's response as they leave the classroom
The bugs are squashed under Doofenshmirtz's Evil Science 101 book