"I can't very well take over the world until I'm drop-dead gorgeous."
"Curse you, Pinky the Chihuahua!!"
Esmeralda Poofenplotz, more commonly known as Professor Poofenplotz, is a local mad scientist and the nemesis of Agent Pinky, Isabella Garcia-Shapiro's dog. ("Day of the Living Gelatin", "Isabella and the Temple of Sap, "Bee Story")
Poofenplotz has been known of her silly attempts of worldwide domination. Her known schemes so far involve replacing handbags, stealing royal jelly, and searching for strong hairspray (her favorite is "Stiff Beauty" hairspray, which originally was only used by clowns). Needless to say, because of her somewhat arrogant personality, Poofenplotz has failed to know about the flaws of her schemes. And because of that, it has allowed Pinky to defeat her in return, leaving a humiliated Poofenplotz to yell out, "Curse you, Pinky the Chihuahua!", similar to how Heinz Doofenshmirtz says whenever his plans get foiled by Perry the Platypus.
Poofenplotz is concerned about her looks, as she can't take over the world until she feels she looks her best. Doofenshmirtz even wrote her a letter in "Bee Story" where he informed her that her application into membership in L.O.V.E.M.U.F.F.I.N. had been declined due to her schemes being deemed not close to their standards.
- Her evil jingles are "Poofenplotz Evil is Crazy!" and "Poofenplotz reading her junk mail!" , very similar to Doofenshmirtz's evil jingle.
- She bears an uncanny resemblance to the Grinch.
- She bears a slight resemblance to Inspector Initials.
- She also looks and sounds like Judi Dench, the actress who plays M in the more recent James Bond films.
- Her lair/office/home bears some resemblance to Doofenshmirtz Evil Incorporated.
- She appears briefly in "Rollercoaster: The Musical!"
- She may be based on Cruella de Vil due to her wishes to be "Drop-dead gorgeous" and her dislike of dogs.
- Her first name was revealed in "Bee Story"
- She's the troll at the Bridge of Comprehension in "Excaliferb"
- She shares the same first name as the love interest of "Juan" in El Matador De Amor. "(The Great Indoors")
- She is really strict about her appearance especially the hair, she uses "Stiff Beauty" hairspray.
- She makes "-ificators" instead of "-inators." ("Bee Story")
- She is somewhat narcissistic, naming and modeling her vehicles after herself, like the Me-Mobile and the Myselfcopter. "(Isabella and the Temple of Sap, Bee Story)"
- "Isabella and the Temple of Sap" (First appearance)
- "Rollercoaster: The Musical!" (Non-speaking cameo)
- "Bee Story"
- "Day of the Living Gelatin" (Mentioned only)