Esmeralda Poofenplotz

"I can't very well take over the world until I'm drop-dead gorgeous."

- Prof. Poofenplotz

 is the nemesis of Agent Pinky, Isabella Garcia-Shapiro's dog. ("Day of the Living Gelatin", "Isabella and the Temple of Sap")

Her known schemes so far involve replacing handbags and searching for strong hairspray (which her favorite is the Stiff Beauty Hairspray which originally was only used by clowns).

She is concerned about her looks, as she can't take over the world until she feels she looks her best. Otherwise she shares much of Doofenshmirz's personality, including having a vehicle which has her head as the main body and saying "Curse you Pinky the Chihuahua!" when her plans are foiled or go wrong (like Doofenshmirtz).

Background Information

 * Her evil jingle is "Poofenplotz Evil is Crazy!"
 * She bears an uncanny resemblance to the Grinch.
 * She also looks and sounds like Judi Dench, the actress who plays M in the more recent James Bond films.
 * She bears a slight resemblance to Inspector Initials.